منابع مشابه
Role of miR-146a in Immune System and Autoimmunity
MicroRNAs (miRNAs) are small preserved non-coding RNA molecules that regulate gene expression post-transcriptionally by targeting the 3' UTR of mRNAs for translational repression or degradation. The rising evidence has established the significant role of miRNAs within the regulation of immune system and the prevention of autoimmunity. MiR-146a has obtained an importance as a modulator of differ...
متن کاملImmune to autoimmunity
he transcriptional state of a gene is connected to its association with the nuclear pore, according to Jason Casolari, Pamela Silver, and colleagues (Harvard Medical School, Boston, MA). Although the silencing of certain loci was known to rely on their localization to the nuclear periphery, where the pores lie, the new results suggest that yeast pores prefer transcriptionally active genes. “You...
متن کاملT-cell Metabolism as a Target to Control Autoreactive T Cells in β-Cell Autoimmunity
PURPOSE OF REVIEW An increasing body of evidence indicates that bio-energetic metabolism of activated T cells is a potential target to control the autoimmune response in type 1 diabetes (T1D). RECENT FINDINGS T-cell activation and proliferation is linked to the cell capacity to provide sufficient energy and biosynthesis molecules to support T-cell growth and division. This makes T cells susce...
متن کاملrole of mir-146a in immune system and autoimmunity
micrornas (mirnas) are small preserved non-coding rna molecules that regulate gene expression post-transcriptionally by targeting the 3' utr of mrnas for translational repression or degradation. the rising evidence has established the significant role of mirnas within the regulation of immune system and the prevention of autoimmunity. mir-146a has obtained an importance as a modulator of d...
متن کاملMitochondrial Dysfunction and Immune Cell Metabolism in Sepsis
Sepsis is a life threatening condition mediated by systemic infection, but also triggered by hemorrhage and trauma. These are significant causes of organ injury implicated in morbidity and mortality, as well as post-sepsis complications associated with dysfunction of innate and adaptive immunity. The role of cellular bioenergetics and loss of metabolic plasticity of immune cells is increasingly...
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ژورنال
عنوان ژورنال: Clinical & Experimental Immunology
سال: 2019
ISSN: 0009-9104,1365-2249
DOI: 10.1111/cei.13277